Vicks Nyquil is one of the best-selling medications which is commonly used to treat the daily ailments like cold and flu. You must have known this fact already. But this piece of information is not enough to let any drug into your system. So before directing you towards the answer to your query, how long does it take for Nyquil to kick in, I wish to take you through a short guide on this Iconic OTC. Read on.

What Is Nyquil?

Vicks Nyquil is a well known multi-symptom medication that is used in treating the conditions like pain, cold, cough, flu, sinus congestion, sneezing, runny nose, allergies, and upper respiratory infections. It is available in both liquid and capsule forms.

What Does Nyquil Do?

The Nyquil multi-symptom is a combination of analgesic, cough suppressant, antihistamine, and decongestant. Multiple active ingredients found in Nyquil work towards treating a single or group of these symptoms.

The analgesic Ingredient found in Nyquil suppresses the production of a chemical called prostaglandin. When the cells do not release this chemical, pain receptors get nothing to conduct. Apparently our brain will not receive the pain messages. It stops sensing the pain instantly.

The Cough suppressant Ingredients reduce the dry as well as an unproductive cough.

The antihistamine ingredients block the production of histamine that in turn reduces the symptoms such as inflammatory responses, sneezing and watery eyes. It is commonly suggested for those with body pain, fever or aches. It’s also responsible for the sleepiness effect caused by Nyquil.

The decongestant ingredients work by constricting the blood vessels which results in the reduction of swelling in nasal passages.

how long does nyquil take to work

What Does Nyquil Taste Like?

Nyquil is a mix of strongly flavored Ingredients. Though the taste of Nyquil is not something pleasant, definitely it will not be the worst one you have ever tasted. As Nyquil has the alcoholic content, it may feel like taking up a shot but with the flavor of the strong medicine. Vicks offers Nyquil in several different forms that include the alcohol-free version as well.

How Long Does It Take For Nyquil To Kick In?

How Quickly Does Nyquil Start To Effect” box_color=”#77f7e7″ title_color=”#000000″ class=””]

You can pop the pill or ingest the liquid. Whatever the form may be as with all other cold medications, Nyquil takes only 10 minutes to get into the system, and it takes 30 minutes to start fully functional. However, if your brain is hyperactive, it may take 45 to 60 minutes to take effort. Antihistamine ingredient found in Nyquil can trigger drowsiness and put you sleep in no time. So it’s good to take this OTC before your bedtime.

The daytime alternative of Nyquil is called as Dayquil. Dayquil do not have drowsiness-causing antihistamine content except this fact; all other ingredients are same with both Nyquil and Dayquil. So if you are at work and want to stay awake, Dayquil should be your ultimate choice.

How Long Before Bed Should You Take Nyquil?

While taking Nyquil multi-symptom, sleepiness becomes an inevitable side effect. Once you take Nyquil, you will start feeling the drowsiness in the first 10 to 15 minutes. At this stage find a comfortable place and settled down because you will be totally out in the next 10 minutes. There is no sleep like Nyquil Sleep. Have fun!

Tips” box_color=”#77f7e7″ title_color=”#000000″ class=””]If you want to sleep by 11.30 P.M, go to bed as early as 11 P.M.

How Long Does Nyquil Last?

As per the guidelines provided by its manufacturer Vicks, the effect of Nyquil last up to 8 hours. But beware, depending on how much you are sensitive to the sedating properties, this duration may get extended little longer. 6 hours, 8 hours, 10 hours, no matter how many hours you sleep, you would still feel heavy and drowsy for the next few hours. It is advisable to stay away from doing the risky jobs such as driving, handling machinery, finances, etc. until you get back to your feet again.

Sometimes you may even need the whole next day to get over the drowsiness. Here is why. Every 30 Ml of Nyquil has 12.5 Mg of antihistamine content known as doxylamine succinate. 25 mg of this drug reportedly has the half life(t 1/2)of around 10 hours in healthy adults. The rest is self-explanatory.

You can also get each of the following Nyquil Variations in Liquicaps / Caplets forms. Take up the route that you feel the best.

Nyquil Variations” box_color=”#f07800″ title_color=”#626262″ class=””]

Nyquil Variation

Nyquil Ingredients / 30 MLStandard SizesRecommended For
Alcohol-Free Nyquil Cold & Flu (Non-drowsy, Alcohol-free)Acetaminophen 650 mgChlorpheniramine maleate 4 mg, Dextromethorphan HBr 30 mg12 FL OZAches, Sore throat, Fever, Nasal Congestion, Cough
Nyquil Cold & FluAcetaminophen 650 mgDextromethorphan HBr 30 mgDoxylamine succinate 12.5 mg8 FL OZ12 FL OZAches, Sore throat, Fever, Nasal Congestion, Cough
Nyquil SevereAcetaminophen 325 mgDextromethorphan HBr 10 mg, Guaifenesin 200 mg Phenylephrine HCl 5 mg12 OZRunny nose, cough, pain, Sinus Congestion, Sinus pressure, fever, headache, sore throat

NyQuil™ Cough


Dextromethorphan HBr 30 mgDoxylamine succinate 12.5 mg8 FL12 FL OZRunny nose, cough, sneezing


Recommended Dosage For Cold Symptoms

Usual Adult Dosage

Adults and children over 12 years can take 30 ML of Nyquil for every 6 hours

But make sure you don’t exceed the daily limit of 120 Ml per day.

Usual Pediatric Dosage

Children who fall in the age group 6 to 12 years should not be treated with Nyquil without the doctor’s prescription.

Children who are under 4 years should not be treated with Nyquil.

If Over Dose is Suspected

Tips” box_color=”#ffeaea” title_color=”#000000″ class=””]

Immediately contact one of your nearest poison control centers or make an emergency call to the Toll-free number 1-800-222-1222.(For United States)

Final Words

Regardless of how long does it take for Nyquil to kick in or how long does Nyquil last, the relief provided by this medication is only temporary. Whatever the symptoms you had before taking this medication will return once its effect fade away. This condition is okay for minor aches. But If you have any serious illnesses that continue for more than 3 days, check with your physician before it gets serious.

Leave a Reply

Notify of